Entity Central Index Key
Operating Lease Imputed interest.
Cover [Abstract]
Entity Registrant Name
Entity Registrant Name
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Trading Symbol
Trading Symbol
Document Type
Document Type
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Well-known Seasoned Issuer
Entity Well Known Seasoned Issuer
Entity Current Reporting Status
Entity Current Reporting Status
Entity Voluntary Filers
Entity Voluntary Filers
Entity Filer Category
Entity Filer Category
Entity Small Business
Entity Small Business
Entity Emerging Growth Company
Entity Emerging Growth Company
Entity Ex Transition Period
Entity Ex Transition Period
Entity Shell Company
Entity Shell Company
Entity Common Stock, Shares Outstanding
Entity Common Stock Shares Outstanding
Entity Public Float
Entity Public Float
Entity Interactive Data Current
Entity Interactive Data Current
Title of 12(b) Security
Security12b Title
Security Exchange Name
Security Exchange Name
Entity File Number
Entity File Number
Entity Incorporation, State or Country Code
Entity Incorporation State Country Code
Entity Tax Identification Number
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address Address Line1
Entity Address, Address Line Two
Entity Address Address Line2
Entity Address, City or Town
Entity Address City Or Town
Entity Address, State or Province
Entity Address State Or Province
Entity Address, Postal Zip Code
Entity Address Postal Zip Code
City Area Code
City Area Code
Local Phone Number
Local Phone Number
Document Annual Report
Document Annual Report
Document Transition Report
Document Transition Report
Documents Incorporated by Reference
Documents Incorporated By Reference [Text Block]
Statement Of Financial Position [Abstract]
Assets
Assets [Abstract]
Current assets:
Assets Current [Abstract]
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Short-term investments
Available For Sale Securities Debt Securities Current
Prepaid expenses
Prepaid Expense Current
Other current assets
Other Assets Current
Total current assets
Assets Current
Property and equipment, net
Property Plant And Equipment Net
Operating lease right-of-use asset
Operating Lease Right Of Use Asset
Restricted cash
Restricted Cash And Cash Equivalents Noncurrent
Other assets
Other Assets Noncurrent
Total assets
Assets
Liabilities, convertible preferred stock and stockholders’ equity
Liabilities And Stockholders Equity [Abstract]
Current liabilities:
Liabilities Current [Abstract]
Accounts payable
Accounts Payable Current
Accrued liabilities
Accrued Liabilities Current
Current portion of long-term debt
Long Term Debt Current
Current portion of operating lease liabilities
Operating Lease Liability Current
Current portion of deferred rent
Deferred Rent Credit Current
Deferred revenue
Deferred Revenue Current
Total current liabilities
Liabilities Current
Long-term debt
Long Term Debt Noncurrent
Operating lease liabilities
Operating Lease Liability Noncurrent
Deferred rent
Deferred Rent Credit Noncurrent
Total liabilities
Liabilities
Commitments and contingencies
Commitments And Contingencies
Stockholders’ equity:
Stockholders Equity [Abstract]
Preferred stock, $0.001 par value; 10,000,000 shares authorized and no shares issued at December 31, 2019 and 2018
Preferred Stock Value
Common stock, $0.001 par value; 100,000,000 shares authorized at December 31, 2019 and 2018; 44,413,372 and 32,119,227 shares issued and outstanding at December 31, 2019 and 2018, respectively
Common Stock Value
Additional paid-in capital
Additional Paid In Capital
Accumulated deficit
Retained Earnings Accumulated Deficit
Total stockholders’ equity
Stockholders Equity
Total liabilities and stockholders’ equity
Liabilities And Stockholders Equity
Preferred stock, par value
Preferred Stock Par Or Stated Value Per Share
Preferred stock, shares authorized
Preferred Stock Shares Authorized
Preferred stock, shares issued
Preferred Stock Shares Issued
Common stock, par value
Common Stock Par Or Stated Value Per Share
Common stock, shares authorized
Common Stock Shares Authorized
Common stock, shares, issued
Common Stock Shares Issued
Common stock, shares outstanding
Common Stock Shares Outstanding
Income Statement [Abstract]
License and other revenue
Revenue From Contract With Customer Excluding Assessed Tax
Type of Revenue [Extensible List]
Type Of Revenue Extensible List
Operating expenses:
Operating Expenses [Abstract]
Research and development
Research And Development Expense
General and administrative
General And Administrative Expense
Total operating expenses
Operating Expenses
Loss from operations
Operating Income Loss
Other (expense) income
Nonoperating Income Expense
Net loss
Net Income Loss
Net loss per share of common stock — basic and diluted
Earnings Per Share Basic And Diluted
Weighted average shares outstanding — basic and diluted
Weighted Average Number Of Share Outstanding Basic And Diluted
Net loss
Unrealized gain on available-for-sale investments
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
Comprehensive loss
Comprehensive Income Net Of Tax
Stock issued during period shares follow on offering.
Stock issued during period value follow on offering.
Stock issued during period shares at market sales agreement.
Stock issued during period value at market sales agreement.
Statement Of Stockholders Equity [Abstract]
Statement [Table]
Statement [Table]
Equity Components
Statement Equity Components [Axis]
Equity Component
Equity Component [Domain]
Common Stock
Common Stock [Member]
Additional Paid-In-Capital
Additional Paid In Capital [Member]
Accumulated Deficit
Retained Earnings [Member]
Accumulated Other Comprehensive Loss
Accumulated Other Comprehensive Income [Member]
Sale of Stock
Subsidiary Sale Of Stock [Axis]
Sale of Stock
Sale Of Stock Name Of Transaction [Domain]
Private Placement
Private Placement [Member]
Statement [Line Items]
Statement [Line Items]
Beginning balance
Beginning balance, shares
Shares Outstanding
Cumulative effect of accounting change
Cumulative Effect On Retained Earnings Net Of Tax1
Issuance of common stock in follow-on offering
Stock Issued During Period Value Follow On Offering
Issuance of common stock in follow-on offering, shares
Stock Issued During Period Shares Follow On Offering
Issuance of common shares from at-the-market sales agreement
Stock Issued During Period Value At Market Sales Agreement
Issuance of common shares from at-the-market sales agreement, shares
Stock Issued During Period Shares At Market Sales Agreement
Issuance of common shares in private placement
Stock Issued During Period Value New Issues
Issuance of common shares from private placement, shares
Stock Issued During Period Shares New Issues
Issuance of common shares under employee stock purchase plan
Stock Issued During Period Value Employee Stock Purchase Plan
Issuance of common shares under employee stock purchase plan, shares
Stock Issued During Period Shares Employee Stock Purchase Plans
Exercise of stock options
Stock Issued During Period Value Stock Options Exercised
Exercise of stock options, shares
Stock Issued During Period Shares Stock Options Exercised
Vesting and settlement of restricted stock units
Stock Issued During Period Value Restricted Stock Award Net Of Forfeitures
Vesting and settlement of restricted stock units, shares
Stock Issued During Period Shares Restricted Stock Award Net Of Forfeitures
Share-based compensation expense
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Other comprehensive gain
Other Comprehensive Income Loss Net Of Tax
Ending balance
Ending balance, shares
Proceeds from the issuance of shares under an at-the-market sales agreement.
Proceeds from issuance follow on offering.
Noncash tenant improvements paid by landlord.
Statement Of Cash Flows [Abstract]
Operating activities
Net Cash Provided By Used In Operating Activities [Abstract]
Net loss
Profit Loss
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Depreciation
Depreciation
Share-based compensation expense
Share Based Compensation
Non-cash interest expense
Paid In Kind Interest
Accretion of debt discount
Deferred Finance Costs Own Share Lending Arrangement Issuance Costs Amortization Expense1
Loss on disposal of fixed assets
Gain Loss On Sale Of Property Plant Equipment
Amortization and accretion on available-for-sale investments, net
Accretion Amortization Of Discounts And Premiums Investments
Changes in operating assets and liabilities:
Increase Decrease In Operating Capital [Abstract]
Prepaid expenses and other current assets
Increase Decrease In Prepaid Deferred Expense And Other Assets
Other assets and liabilities
Increase Decrease In Other Operating Capital Net
Accounts payable and accrued liabilities
Increase Decrease In Accounts Payable And Accrued Liabilities
Deferred revenue
Increase Decrease In Contract With Customer Liability
Net cash used in operating activities
Net Cash Provided By Used In Operating Activities
Investing activities
Net Cash Provided By Used In Investing Activities [Abstract]
Maturities of available-for-sale-investments
Proceeds From Sale And Maturity Of Available For Sale Securities
Purchase of available-for-sale investments
Payments To Acquire Available For Sale Securities Debt
Acquisition of property and equipment
Payments To Acquire Property Plant And Equipment
Net cash provided by (used in) investing activities
Net Cash Provided By Used In Investing Activities
Financing activities
Net Cash Provided By Used In Financing Activities [Abstract]
Proceeds from at-the-market sales agreement, net of issuance costs
Proceeds From Issuance At The Market
Proceeds from private placement, net of issuance costs
Proceeds From Issuance Of Private Placement
Proceeds from follow-on offering, net of issuance costs
Proceeds From Issuance Follow On Offering
Proceeds from exercise of stock options
Proceeds From Stock Options Exercised
Proceeds from shares issued under employee stock purchase plan
Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans
Proceeds from issuance of long-term debt
Proceeds From Issuance Of Long Term Debt
Principal payments made on long-term debt
Repayments Of Long Term Debt
Net cash provided by financing activities
Net Cash Provided By Used In Financing Activities
Net decrease in cash, cash equivalents and restricted cash
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
Cash, cash equivalents and restricted cash, beginning of period
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
Cash, cash equivalents and restricted cash, end of period
Supplemental disclosure
Supplemental Cash Flow Information [Abstract]
Interest paid
Interest Paid Net
Tenant improvements paid by landlord
Noncash Tenant Improvements Paid By Landlord
Reconciliation of cash, cash equivalents and restricted cash.
Reconciliation of cash, cash equivalents and restricted cash;
Reconciliation Of Cash Cash Equivalents And Restricted Cash [Abstract]
Cash and cash equivalents
Restricted cash
Restricted Cash
Organization Consolidation And Presentation Of Financial Statements [Abstract]
The Company
Organization Consolidation And Presentation Of Financial Statements Disclosure [Text Block]
Accounting Policies [Abstract]
Significant Accounting Policies
Significant Accounting Policies [Text Block]
Property Plant And Equipment [Abstract]
Property and Equipment, Net
Property Plant And Equipment Disclosure [Text Block]
Payables And Accruals [Abstract]
Accrued Liabilities
Accounts Payable Accrued Liabilities And Other Liabilities Disclosure Current [Text Block]
Debt Disclosure [Abstract]
Long-Term Debt
Long Term Debt [Text Block]
Equity [Abstract]
Preferred and Common Stock
Stockholders Equity Note Disclosure [Text Block]
Common stock warrants disclosure.
Common stock warrants abstract.
Common Stock Warrants [Abstract]
Common Stock Warrants
Common Stock Warrants Disclosure [Text Block]
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Share-Based Compensation
Disclosure Of Compensation Related Costs Share Based Payments [Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies
Commitments And Contingencies Disclosure [Text Block]
License and other agreements disclosure.
License and other agreement.
License And Other Agreement [Abstract]
License and Other Agreements
License And Other Agreements Disclosure [Text Block]
Fair Value Disclosures [Abstract]
Fair Value Measurements
Fair Value Disclosures [Text Block]
Earnings Per Share [Abstract]
Net Loss Per Share
Earnings Per Share [Text Block]
Related Party Transactions [Abstract]
Summary of Related Party Transactions Disclosure
Related Party Transactions Disclosure [Text Block]
Quarterly Financial Data [Abstract]
Quarterly Financial Information (Unaudited)
Quarterly Financial Information [Text Block]
Subsequent Events [Abstract]
Subsequent Event
Subsequent Events [Text Block]
Basis of Presentation
Basis Of Accounting Policy Policy [Text Block]
Use of Estimates
Use Of Estimates
Revenue Recognition
Revenue From Contract With Customer Policy [Text Block]
Segment Information
Segment Reporting Policy Policy [Text Block]
Property and Equipment, Net
Property Plant And Equipment Policy [Text Block]
Debt Discount
Debt Policy [Text Block]
Fair Value Measurements
Fair Value Measurement Policy Policy [Text Block]
Income Taxes
Income Tax Policy [Text Block]
Research and Development Costs
Research And Development Expense Policy
Share-Based Compensation
Compensation Related Costs Policy [Text Block]
Cash Equivalents
Cash And Cash Equivalents Policy [Text Block]
Short-Term Investments
Marketable Securities Policy
Restricted Cash
Cash And Cash Equivalents Restricted Cash And Cash Equivalents Policy
Concentration of Credit Risk Arising From Cash Deposits in Excess of Insured Limits
Concentration Risk Credit Risk
Recent Accounting Pronouncements
New Accounting Pronouncements Policy Policy [Text Block]
Schedule of Property and Equipment, Net
Property Plant And Equipment [Text Block]
Schedule of Accrued Liabilities
Schedule Of Accrued Liabilities Table [Text Block]
Scheduled Payments for the Loan Agreement
Schedule Of Maturities Of Long Term Debt Table [Text Block]
Award Type
Award Type [Axis]
Award Type
Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]
Restricted Stock Units (RSUs)
Restricted Stock Units R S U [Member]
Plan Name
Plan Name [Axis]
Plan Name
Plan Name [Domain]
Two thousand sixteen employee stock purchase plan.
2016 Employee Stock Purchase Plan
Two Thousand Sixteen Employee Stock Purchase Plan [Member]
Summary of Share-based Compensation Expense
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block]
Weighted Average Assumptions Used in Black-Scholes Option Pricing Model to Calculate Fair Value of Underlying Common Stock
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block]
Summary of Activity Related to Stock Options
Schedule Of Share Based Compensation Stock Options Activity Table [Text Block]
Additional Information about the Stock Option Outstanding and Exercisable
Schedule Of Share Based Compensation Stock Options And Stock Appreciation Rights Award Activity Table [Text Block]
Summary of the Activity Related to RSUs
Schedule Of Nonvested Share Activity Table [Text Block]
Schedule of Net Deferred Tax Assets
Schedule Of Deferred Tax Assets And Liabilities Table [Text Block]
Schedule of Statutory and Effective Income Tax Rate Reconciliation
Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block]
Schedule of operating leases assets and liabilities.
Operating Leases Included on the Balance Sheet
Schedule Of Operating Leases Assets And Liabilities
Future Minimum Commitments Due Under Non-Cancelable Operating Leases
Schedule Of Future Minimum Rental Payments For Operating Leases Table [Text Block]
Summary of Assets and Liabilities Measured at Fair Value
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Table [Text Block]
Potential Common Stock Equivalents Excluded from Computation of Diluted Net Loss per Share
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block]
Summary of Quarterly Financial Information
Schedule Of Quarterly Financial Information Table [Text Block]
Entity incorporation date
Entity Incorporation Date Of Incorporation
Cash and cash equivalents
Significant accounting policies.
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Adjustments for New Accounting Pronouncements
Adjustments For New Accounting Pronouncements [Axis]
Type of Adoption
Type Of Adoption [Member]
ASU 2016-02
Accounting Standards Update201602 [Member]
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Line Items]
Number of operating segments
Number Of Operating Segments
Short term investments, maturity period range start.
Short term investments, maturity period range end.
Short-term investments maturity start period
Short Term Investments Maturity Period Range Start
Short-term investments maturity end period
Short Term Investments Maturity Period Range End
Recognition of a right-of use asset
Recognition of a lease obligations
Operating Lease Liability
Schedule Of Property Plant And Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment, Type
Property Plant And Equipment By Type [Axis]
Property, Plant and Equipment, Type
Property Plant And Equipment Type [Domain]
Furniture and Fixtures
Furniture And Fixtures [Member]
Machinery and Equipment
Machinery And Equipment [Member]
Computer Equipment
Computer Equipment [Member]
Leasehold Improvements
Leasehold Improvements [Member]
Property Plant And Equipment [Line Items]
Property Plant And Equipment [Line Items]
Total property and equipment
Property Plant And Equipment Gross
Less: Accumulated depreciation
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
Property and equipment, net
Estimated Useful Lives (Years)
Property Plant And Equipment Useful Life
Estimated Useful Lives (Years)
Property Plant And Equipment Estimated Useful Lives
Accrued research and development expenses.
Accrued severance costs.
Accrued research and development
Accrued Research And Development Expenses
Accrued employee costs
Employee Related Liabilities Current
Accrued severance
Accrued Severance Costs
Accrued professional fees
Accrued Professional Fees Current
Accrued interest payable
Interest Payable Current
Accrued expense
Other Accrued Liabilities Current
Accrued liabilities, current
Debt Instruments [Abstract]
Debt Instrument [Table]
Debt Instrument [Table]
Lender Name
Line Of Credit Facility [Axis]
Line of Credit Facility, Lender
Line Of Credit Facility Lender [Domain]
Silicon Valley Bank, MidCap funding XII trust and MidCap financial trust.
Silicon Valley Bank , MidCap Funding XII Trust and MidCap Financial Trust
Silicon Valley Bank Mid Cap Funding X I I Trust And Mid Cap Financial Trust [Member]
Debt Instrument
Debt Instrument [Axis]
Debt Instrument, Name
Debt Instrument Name [Domain]
First amended and restated loan and security agreement.
First Amended and Restated Loan and Security Agreement
First Amended And Restated Loan And Security Agreement [Member]
Debt Instrument, Redemption, Period
Debt Instrument Redemption Period [Axis]
Debt Instrument, Redemption, Period
Debt Instrument Redemption Period [Domain]
Prepayments Through May 31, 2020
Debt Instrument Redemption Period One [Member]
Silicon Valley Bank, MidCap funding III trust and MidCap financial trust.
Silicon Valley Bank, MidCap Funding III Trust and MidCap Financial Trust
Silicon Valley Bank Mid Cap Funding I I I Trust And Mid Cap Financial Trust [Member]
Second amended and restated loan and security agreement.
Second Amended and Restated Loan and Security Agreement
Second Amended And Restated Loan And Security Agreement [Member]
Credit Facility
Credit Facility [Axis]
Credit Facility
Credit Facility [Domain]
Final payment.
Final Payment
Final Payment [Member]
Term C loan.
Term C Loan
Term C Loan [Member]
Second amended and restated loan and security agreement, first tranche.
Second Amended and Restated Loan and Security Agreement, Initial Tranche
Second Amended And Restated Loan And Security Agreement First Tranche [Member]
Third amended and restated loan and security agreement.
Third Amended And Restated Loan And Security Agreement
Third Amended And Restated Loan And Security Agreement [Member]
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Fixed interest rate
Debt Instrument Interest Rate Stated Percentage
Variable interest rate
Debt Instrument Basis Spread On Variable Rate1
Debt instrument, description of variable rate basis
Debt Instrument Description Of Variable Rate Basis
Line of credit facility, maximum borrowing capacity
Line Of Credit Facility Maximum Borrowing Capacity
Prepayment fee percentage of original principal amount of the aggregate term loans.
Long term debt
Long Term Debt
Line of credit facility, remaining borrowing capacity
Line Of Credit Facility Remaining Borrowing Capacity
Line of credit facility, expiration date
Line Of Credit Facility Expiration Date1
Debt instrument, payment terms
Debt Instrument Payment Terms
Prepayment fee percentage of the original principal amount of the aggregate term loans
Prepayment Fee Percentage Of Original Principal Amount Of The Aggregate Term Loans
Final payment during maturity
Debt Instrument Periodic Payment Terms Balloon Payment To Be Paid
Debt instrument, maturity date
Debt Instrument Maturity Date
Repayment of outstanding amount under the loan agreement including fees
Repayments Of Debt
Line of credit facility remaining borrowing capacity not available for withdraw.
Line of credit facility, remaining borrowing capacity description
Debt Instrument Unused Borrowing Capacity Description
Line of credit facility remaining borrowing capacity not available for withdraw
Line Of Credit Facility Remaining Borrowing Capacity Not Available For Withdraw
Debt instrument final payment fee
Minimum balance requirement for cash and cash equivalents.
Debt instrument final payment percentage.
Debt instrument final payment
Debt Instrument Final Payment Fee
Minimum balance requirement cash and cash equivalents
Minimum Balance Requirement Cash And Cash Equivalents
Final payment during maturity, percentage
Debt Instrument Final Payment Percentage
Accretion of final payment of amount borrowed.
Accretion of deferred closing costs.
Interest expense on borrowings
Interest Expense Borrowings
Accretion of scheduled final payment
Accretion Of Final Payment Of Amount Borrowed
Accretion of deferred closing costs
Accretion Of Deferred Closing Costs
Long term debt maturities repayments of principal, interest and final payment.
Long term debt maturities repayments of principal, interest and final payment in next twelve months.
Long term debt maturities repayments of principal, interest and final payment in year two.
Long term debt maturities repayments of principal, interest and final payment in year three.
Long term debt maturities repayments of interest and final payment.
Long term debt maturities repayments of interest and final payment in next twelve months.
Long term debt maturities repayments of interest and final payment in year two.
Long term debt maturities repayments of interest and final payment in year three.
Principal, 2020
Long Term Debt Maturities Repayments Of Principal In Next Twelve Months
Principal, 2021
Long Term Debt Maturities Repayments Of Principal In Year Two
Principal, 2022
Long Term Debt Maturities Repayments Of Principal In Year Three
Principal
Interest and Final Payment, 2020
Long Term Debt Maturities Repayments Of Interest And Final Payment In Next Twelve Months
Interest and Final Payment, 2021
Long Term Debt Maturities Repayments Of Interest And Final Payment In Year Two
Interest and Final Payment, 2022
Long Term Debt Maturities Repayments Of Interest And Final Payment In Year Three
Interest and Final Payment
Long Term Debt Maturities Repayments Of Interest And Final Payment
Total, 2020
Long Term Debt Maturities Repayments Of Principal Interest And Final Payment In Next Twelve Months
Total, 2021
Long Term Debt Maturities Repayments Of Principal Interest And Final Payment In Year Two
Total, 2022
Long Term Debt Maturities Repayments Of Principal Interest And Final Payment In Year Three
Total
Long Term Debt Maturities Repayments Of Principal Interest And Final Payment
Preferred stock, shares outstanding
Preferred Stock Shares Outstanding
Warrants expiration term.
Class Of Warrant Or Right [Table]
Class Of Warrant Or Right [Table]
Common stock warrants.
Convertible Stock Warrant
Common Stock Warrants [Member]
Statistical Measurement
Range [Axis]
Statistical Measurement
Range [Member]
Maximum
Maximum [Member]
Minimum [Member]
Minimum [Member]
Class Of Warrant Or Right [Line Items]
Class Of Warrant Or Right [Line Items]
Number of stock that can be purchased by each warrant
Class Of Warrant Or Right Number Of Securities Called By Each Warrant Or Right
Class of warrant Exercise
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1
Warrants expiration term
Warrants Expiration Term
Weighted average remaining life of warrants
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Outstanding Weighted Average Remaining Contractual Terms
Share based compensation arrangement by share based payment award increase in number of shares reserved for issuance percentage.
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Stock Options
Employee Stock Option [Member]
2016 Plan.
2016 Stock Incentive Plan
Two Thousand Sixteen Equity Incentive Plan [Member]
2011 Plan.
2011 Stock Incentive Plan
Two Thousand Eleven Stock Incentive Plan [Member]
Subsequent Event Type
Subsequent Event Type [Axis]
Subsequent Event Type
Subsequent Event Type [Domain]
Subsequent Event
Subsequent Event [Member]
Income Statement Location
Income Statement Location [Axis]
Income Statement Location
Income Statement Location [Domain]
Research And Development
Research And Development Expense [Member]
General and Administrative
General And Administrative Expense [Member]
Two thousands and sixteen employee stock purchase plan.
2016 Employee Stock Purchase Plan
Two Thousands And Sixteen Employee Stock Purchase Plan [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share based compensation arrangement description
Share Based Compensation Arrangement By Share Based Payment Award Description
Annual increase of common stock reserved for issuance
Share Based Compensation Arrangement By Share Based Payment Award Increase In Number Of Shares Reserved For Issuance Percentage
Number of shares grants
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Option to purchase common stock shares outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Weighted average exercise price
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Shares available for future grant
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant
Increase in common stock for future issuance, shares
Share Based Compensation Arrangement By Share Based Payment Award Number Of Additional Shares Authorized
Shares common stock reserved for issuance
Common Stock Capital Shares Reserved For Future Issuance
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Research and Development
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Share-based compensation expense
Allocated Share Based Compensation Expense
Expected term (years)
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
Expected stock price volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate
Risk-free interest rate
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate
Expected dividend yield
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
Number of Shares, Options outstanding, Beginning balance
Number of Shares, Granted
Number of Shares, Exercised
Number of Shares, Cancelled/Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period
Number of Shares, Options outstanding, Ending balance
Number of Shares, Options exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
Weighted Average Exercise Price, Options outstanding, Beginning balance
Weighted Average Exercise Price, Granted
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Weighted Average Exercise Price, Exercised
Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price
Weighted Average Exercise Price, Cancelled/Forfeited
Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price
Weighted Average Exercise Price, Options outstanding, Ending balance
Weighted Average Exercise Price, Options exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
Schedule Of Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range [Table]
Schedule Of Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range [Table]
Exercise Price Range
Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range [Axis]
Exercise Price Range
Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range [Domain]
Range one.
$0.00 - $2.99
Range One [Member]
Range two.
$3.00 - $6.99
Range Two [Member]
Range three.
$7.00 - $8.99
Range Three [Member]
Range four.
$9.00 - $20.84
Range Four [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range [Line Items]
Exercise Price Lower Range Limit
Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range Lower Range Limit
Exercise Price Upper Range Limit
Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range Upper Range Limit
Options Outstanding
Weighted Average Exercise Price
Aggregate Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Weighted Average Remaining Contractual Life (Years)
Sharebased Compensation Shares Authorized Under Stock Option Plans Exercise Price Range Outstanding Options Weighted Average Remaining Contractual Term2
Options Exercisable
Weighted Average Exercise Price
Aggregate Intrinsic Value
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1
Weighted Average Remaining Contractual Life (Years)
Sharebased Compensation Shares Authorized Under Stock Option Plans Exercise Price Range Exercisable Options Weighted Average Remaining Contractual Term2
Common stock fair market value per share.
Unrecognized compensation expense related to unvested stock options
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
Expected to be recognized over a weighted average period
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
Weighted-average fair values granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
Fair market value per share of common stock
Common Stock Fair Market Value Per Share
Non-vested units outstanding, Number of Shares, Beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number
Number of Shares, Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period
Number of Shares, Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period
Non-vested units outstanding, Number of Shares, Ending balance
Non-vested units outstanding, Weighted Average Grant Date Fair Value, Beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value
Non-vested units outstanding, Weighted Average Grant Date Fair Value, Ending balance
Unrecognized compensation expense related to the RSUs
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Share Based Awards Other Than Options
Employee stock purchase plan payroll deduction as percentage of regular employee earnings maximum.
Common stock available for issuance increase in period.
Addition of common stock shares reserved for future issuance.
Employee payroll deductions, percent
Employee Stock Purchase Plan Payroll Deduction As Percentage Of Regular Employee Earnings Maximum
Number of shares reserved for issuance increase in years
Common Stock Available For Issuance Increase In Period
Addition of common stock shares reserved for future issuance
Addition Of Common Stock Shares Reserved For Future Issuance
Common stock purchased
Income tax disclosure line items.
Income tax disclosure table.
Income Tax Disclosure [Table]
Income Tax Disclosure [Table]
Income Tax Authority
Income Tax Authority [Axis]
Income Tax Authority
Income Tax Authority [Domain]
US federal state income tax.
U.S. Federal or State Income Taxes
U S Federal State Income Tax [Member]
Federal
Domestic Country [Member]
State
State And Local Jurisdiction [Member]
Tax Period
Tax Period [Axis]
Tax Period
Tax Period [Domain]
Earliest Tax Year
Earliest Tax Year [Member]
Income Tax Disclosure [Line Items]
Income Tax Disclosure [Line Items]
Provision for income taxes
Income Tax Expense Benefit
Deferred tax assets tax non deductible accruals accrued expenses.
Deferred tax liabilities right of use assets.
Deferred tax assets lease liability.
Deferred tax liabilities depreciation differences.
Deferred tax assets disallowed interest expense.
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards [Line Items]
Deferred tax asset (liability)
Components Of Deferred Tax Assets And Liabilities [Abstract]
Net operating loss carryforwards
Deferred Tax Assets Operating Loss Carryforwards
Non-deductible accrued expenses
Deferred Tax Assets Tax Non Deductible Accruals Accrued Expenses
Right of use asset
Deferred Tax Liabilities Right Of Use Assets
Lease liability
Deferred Tax Assets Lease Liability
Deferred rent
Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Deferred Rent
Deferred revenue
Deferred Tax Assets Deferred Income
Stock compensation expense
Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
Depreciation differences
Deferred Tax Liabilities Depreciation Differences
Tax credits
Deferred Tax Assets Tax Credit Carryforwards
Disallowed interest expense
Deferred Tax Assets Disallowed Interest Expense
Charitable contributions
Deferred Tax Assets Charitable Contribution Carryforwards
Valuation allowance
Deferred Tax Assets Valuation Allowance
Net deferred tax asset
Deferred Tax Assets Liabilities Net
U.S. federal tax rate
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
State tax rate
Effective Income Tax Rate Reconciliation State And Local Income Taxes
Permanent difference and other
Effective Income Tax Rate Reconciliation Other Adjustments
Tax credit
Effective Income Tax Rate Reconciliation Tax Credits
Valuation allowance
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
ASC 740-10
Effective Income Tax Rate Reconciliation Prior Year Income Taxes
Impact of federal rate change
Effective Income Tax Rate Reconciliation Change In Enacted Tax Rate
Total income tax provision (benefit)
Effective Income Tax Rate Continuing Operations
Tax Cuts and Jobs Act of 2017,Provisional Income Tax Expense
Tax Cuts And Jobs Act Of2017 Change In Tax Rate Income Tax Expense Benefit
Deferred tax assets, valuation allowance
Operating loss carryforwards expiration period.
Net operating loss carryforwards
Operating Loss Carryforwards
Deferred tax assets, operating loss carryforwards
Operating loss carryforwards expiration period
Operating Loss Carryforwards Expiration Period
Operating loss carryforwards, limitations on use
Operating Loss Carryforwards Limitations On Use
Reserve for tax positions of prior years
Unrecognized Tax Benefits Increases Resulting From Prior Period Tax Positions
Base annual rental income fixed percentage increase.
Operating leases rent expense minimum rentals per month.
Square footage of leased office space.
Commitment and Contingencies [Line Items].
Commitment and Contingencies [Table]
Commitment And Contingencies [Table]
Commitment And Contingencies [Table]
Geographical
Statement Geographical [Axis]
Geographical
Segment Geographical [Domain]
GEORGIA
GEORGIA
CALIFORNIA
CALIFORNIA
Collaborative Arrangement and Arrangement Other than Collaborative
Type Of Arrangement [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Arrangements And Nonarrangement Transactions [Member]
Manufacturing Supply Agreement Member.
Manufacturing Supply Agreement
Manufacturing Supply Agreement [Member]
Counterparty Name
Counterparty Name [Axis]
Counterparty Name
Repurchase Agreement Counterparty Name [Domain]
Gerresheimer regensburg GmbH.
Gerresheimer Regensburg GmbH
Gerresheimer Regensburg Gmb H [Member]
Commitment And Contingencies [Line Items]
Commitment And Contingencies [Line Items]
Area of office leased
Area Of Leased Office Space
Operating lease agreement term
Lessee Operating Lease Term Of Contract
Operating lease agreement renewal option term
Lessee Operating Lease Renewal Term
Minimum monthly lease payments
Operating Leases Rent Expense Minimum Rentals Per Month
Percentage of increase per year
Base Annual Rental Income Fixed Percentage Increase
Lease termination date
Lease Expiration Date1
Operating lease liability payments due
Lessee Operating Lease Liability Payments Due
Liabilities
Liabilities [Abstract]
Total operating lease liabilities
Incremental borrowing rate.
Lessee, operating lease, option to extend, description
Lessee Operating Lease Option To Extend
Incremental borrowing rate
Incremental Borrowing Rate
Operating lease, remaining lease term
Operating Lease Weighted Average Remaining Lease Term1
2020
Operating Leases Future Minimum Payments Due Current
2021
Operating Leases Future Minimum Payments Due In Two Years
2022
Operating Leases Future Minimum Payments Due In Three Years
2023
Operating Leases Future Minimum Payments Due In Four Years
Total minimum lease payments
Operating Leases Future Minimum Payments Due
Less imputed interest
Operating Lease Imputed Interest
Total operating lease liabilities
Operating Lease, Cost
Operating Lease Cost
Variable Lease, Cost
Variable Lease Cost
Short-term Lease, Cost
Short Term Lease Cost
Initial Term of Agreement.
Renewal Term of Agreement.
Initial term of agreement
Initial Term Of Agreement
Renewal term of agreement
Renewal Term Of Agreement
Additional milestone payment.
Pre-Launch Milestone Payments.
First cumulative net sales of products.
Upfront payments.
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Research and Development Arrangement, Contract to Perform for Others, Type
Research And Development Arrangement Contract To Perform For Others By Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type
Research And Development Arrangement Contract To Perform For Others Type [Domain]
Bausch health ireland limited (Bausch).
Bausch Lomb
Bausch Health Ireland Limited [Member]
Commercial Arrangement.
Commercial Arrangement
Commercial Arrangement [Member]
Deferred Revenue Arrangement Type
Deferred Revenue Arrangement Type [Axis]
Deferred Revenue
Deferred Revenue Arrangement Type [Domain]
Upfront payment
Up Front Payment Arrangement [Member]
License arrangement.
License Arrangement
License Arrangement [Member]
REGENXBIO, Inc.
REGENXBIO, Inc.
R E G E N X B I O Inc [Member]
Product and Service
Product Or Service [Axis]
Product and Service
Products And Services [Domain]
License
License [Member]
Other Agreements
License And Service [Member]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Upfront payment
Upfront Payments
Pre-launch milestone payments
Pre Launch Milestone Payments
Additional milestone payments
Additional Milestone Payment
First cumulative net sales of products
First Cumulative Net Sales Of Products
Represents the amount of option fee paid.
Milestone payments.
Proceeds from option fee previously received.
Sales-based milestone payments.
Option fee paid
Option Fee Paid
Proceeds from option fee previously received
Proceeds From Option Fee Previously Received
Milestone payments
Milestone Payments
Sales-based milestone payments
Sales Based Milestone Payments
Revenue
Fair value assets between level 1 level 2 and level 3 transfers amount.
Significant transfers between Levels 1, 2 and 3
Fair Value Assets Between Level1 Level2 And Level3 Transfers Amount
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Asset Class
Fair Value By Asset Class [Axis]
Asset Class
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation By Asset Class [Domain]
Cash and money markets.
Cash and Money Markets
Cash And Money Markets [Member]
Restricted cash money market.
Restricted Cash Money Market
Restricted Cash Money Market [Member]
Fair Value Hierarchy and NAV
Fair Value By Fair Value Hierarchy Level [Axis]
Fair Value Hierarchy and NAV
Fair Value Measurements Fair Value Hierarchy [Domain]
Level 1
Fair Value Inputs Level1 [Member]
Level 2
Fair Value Inputs Level2 [Member]
Level 3
Fair Value Inputs Level3 [Member]
Investment Type
Investment Type [Axis]
Investments
Investment Type Categorization [Member]
Treasury Bills
U S Treasury Bill Securities [Member]
Commercial Paper
Commercial Paper [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Financial Assets:
Assets Fair Value Disclosure [Abstract]
Total financial assets
Assets Fair Value Disclosure
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Antidilutive Securities, Name
Antidilutive Securities Name [Domain]
Outstanding Stock Options
Non vested restricted stock units.
Non-vested Restricted Stock Units
Non Vested Restricted Stock Units [Member]
Stock Purchase Warrants
Warrant [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
Schedule Of Related Party Transactions By Related Party [Table]
Schedule Of Related Party Transactions By Related Party [Table]
Related Party
Related Party Transactions By Related Party [Axis]
Related Party
Related Party [Domain]
Hatteras venture partners IV SBIC LP.
Hatteras venture partners IV SBIC, LP
Hatteras Venture Partners I V S B I C L P [Member]
Hatteras venture partners IV LP.
Hatteras venture partners IV, LP
Hatteras Venture Partners I V L P [Member]
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Shares issued, price per share
Shares Issued Price Per Share
Shares, issued
Shares Issued
Operating expenses
Nature of Expense
Nature Of Expense [Axis]
Interim Period, Costs Not Allocable
Interim Period Costs Not Allocable [Domain]
Clinical Trials [Member]
Clinical Trials
Clinical Trials [Member]
SAPHHIRE [Member]
SAPHHIRE
S A P H H I R E [Member]
TOPAZ [Member]
TOPAZ
T O P A Z [Member]
Operating Expenses
Amount of upfront payment and development milestones payment to be received under license agreement.
Development milestone payments.
Threshold percentage of sales for tiered royalties.
Subsequent Event [Table]
Subsequent Event [Table]
Arctic Vision Limited.
Arctic Vision Limited
Arctic Vision Limited [Member]
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Amount of upfront payment and development milestones payment to be received under license agreement
Amount Of Upfront Payment And Development Milestones Payment To Be Received Under License Agreement
Development milestone payments
Development Milestone Payments
Threshold percentage of sales for tiered royalties
Threshold Percentage Of Sales For Tiered Royalties